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Pfizer, Moderna seen reaping billions from COVID-19 vaccine booster market
COVID-19 vaccine market booms; Pfizer, Moderna to gain billions
Pfizer, Moderna seen reaping billions from COVID-19 vaccine booster market

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NEW YORK, Aug 13 (Reuters) - Drugmakers Pfizer Inc, BioNTech and Moderna Inc are expected to reap billions of dollars from COVID-19 booster shots in a market that could rival the $6 billion in annual sales for flu vaccines for years to come, analysts and healthcare investors say.



For several months, the companies have said they expect that fully inoculated people will need an extra dose of their vaccines to maintain protection over time and to fend off new coronavirus variants.

Now a growing list of governments, including Chile, Germany and Israel, have decided to offer booster doses to older citizens or people with weak immune systems in the face of the fast-spreading Delta variant.

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New York City will require all 148,000 city Department of Education workers, including teachers, principals, custodians, cafeteria workers, and central office staff, to get at least one dose of a Covid-19 vaccine by Sept. 27, Mayor Bill de Blasio announced on Monday. Now that the Food and Drug Administration has approved the Pfizer –

VANCOUVER (Reuters) - The Canadian province of British Columbia will require patrons of non-essential businesses such as restaurants and movie theatres to be vaccinated against COVID-19 from Sept. 13, the government said on Monday.
The vaccine requirement will also cover fitness studios along with sporting events, concerts, weddings and other private and public indoor social events, health officials said.



British Columbia, Canada's westernmost province, is reporting some of the country's highest rates of new COVID-19 cases per capita and recently mandated vaccines for staff of long-term care homes. The province reported 663 new cases on Friday, the most recent data available.
People wanting to enter a non-essential business must have at least one dose of vaccine starting Sept. 13 and both doses by Oct. 24, Premier John Horgan said.
"There's no reason those who are anxious to participate in the social and economic life of our community can't take that next step and get that safe, effective vaccine," Horgan told reporters.
Quebec was the first province to bring in vaccine passports for non-essential businesses earlier in August.
Vaccine mandates are becoming an election issue in Canada's ongoing federal election, which Prime Minister Justin Trudeau triggered on Aug. 15.
Trudeau's centre-left Liberal party brought in mandatory vaccines for federal workers before the election was called and has supported calls for further mandates, as have the left-leaning New Democrats. Canada's Conservative party has said such mandates would impede individual freedom.
Currently, 73% of Canadians aged 12 and over are fully vaccinated, according to government data. The majority of Canadians are in favour of widespread vaccine mandates, a poll by Nanos Research in early August found, with 74% supporting or somewhat supporting such a measure.

The Food and Drug Administration gave the green light to the Pfizer-BioNTech vaccine, as COVID-19 cases soar across the U.S.

[*]



Update: On Monday, August 23, the FDA approved the Pfizer/BioNTech COVID-19 vaccine, making it the first officially licensed vaccine against the coronavirus. In a briefing call on Monday, acting FDA Commissioner Dr. Janet Woodcock said that Americans should now feel fully confident in vaccination efforts going forward. “While this and other vaccines have met the FDA’s rigorous scientific standards for emergency use authorization, as the first FDA approved COVID-19 vaccine, the public can be confident that this vaccine meets the FDA’s gold standard for safety, effectiveness and manufacturing quality that we require for an approved product,” Woodcock said.
While this is the fastest vaccine approval in the agency’s history, coming nearly four months after Pfizer filed for licensing, experts have ensured that the speedy approval is merely a reflection of scientists working day and night on data analysis and risk-benefit assessment. This approval will now last indefinitely, unlike the emergency approval, and the agency hopes it will convince more Americans to pursue inoculation.
This story was originally published on August 6, 2021.

Due to the numerous COVID-19 variants that are believed to be more resistant to vaccines, and an alarming rise in COVID cases and hospitalizations, the Federal Drug Administration (FDA) is accelerating their vaccine approval process for the two-shot Pfizer vaccine. While President Joe Biden said the process was initially set to be completed by the fall, people familiar with the administration’s plan say the unofficial approval deadline is Labor Day — if not sooner.
Currently, the two-shot Pfizer and Moderna vaccines, as well as the one-shot Johnson & Johnson vaccine, have an FDA-granted emergency use authorization. This allows drug manufacturers who have met a series of scientific and regulatory criteria to provide lifesaving medicines, like vaccines, that have not been fully approved to be used in the event of a public health emergency. Once emergency use authorization is granted, the FDA puts in place a series of “existing vaccine safety monitoring systems” during the post-authorization and approval period, as per the administration’s website. Multiple studies have shown that all three of the COVID-19 vaccinations distributed in the United States are both safe and effective, even among the COVID variants.
And now that cases are rising in all 50 states and the country is experiencing thousands of new cases a day, due in no small part to the Delta variant — as well as other mutations of the virus, like Delta Plus and the Lambda variant — there’s an even greater need to get as many Americans who are eligible for the vaccine inoculated.
Currently, Mississippi and Louisiana have some of the worst vaccination rates per state in the entire country, and as a result have seen the number of positive COVID cases jump more than 132% and are experiencing a weekly average of 910 new cases per day. The number of Americans hospitalized with COVID-19 has increased by 60% — a frightening statistic, given that a recent study found that when every bed is full in an ICU unit, patients’ risk of dying from COVID increase by 92%.
Still, some have been hesitant to get vaccinated as the vaccines have not been fully approved. A recent Kaiser Family Foundation poll found that three out of every 10 people who have yet to receive their first dose of a vaccine said they would be more likely to get a shot if the vaccines were fully approved, which is why the FDA is hoping to speed up the process. In a written statement, FDA leaders “recognized that approval might inspire more public confidence and had taken an all-hands-on-deck approach” to the work, as reported by The New York Times.
“As we know, a lot of people are potentially on the fence waiting for that to happen,” Dr. Mark Steele, executive chief clinical officer at Truman Medical Centers/University Health in Kansas City, told local news network and NBC affiliate KSHB-TV. “If that were to occur I think that would be hopefully a big boost to getting more people vaccinated.”
Once the Pfizer vaccine is fully approved, the FDA will likely fully approve the additional available vaccines as well, making it that much easier for businesses, federal government agencies, and other institutions to mandate employees and patrons be fully vaccinated — edging us ever closer to herd immunity and the chance of protecting more people, including those too young to receive a vaccine yet or those who are immunocompromised, from this deadly virus. But for now, unvaccinated people are still urged to reconsider waiting for a piece of paper to protect themselves from spreading COVID to family, friends, and neighbors.

At this moment, the molecules that form the genetic code of the virus that causes Covid-19 are reshuffling themselves in the cells of millions of people around the world. Much depends on how those molecular cards flop.
Since the Delta variant set off a deadly wave of Covid infections in India six months ago, the fight against the pandemic has been changing. Now, the U.S. is reporting more than 140,000 new cases a day, and hospitals are beginning to buckle in some parts of the country.
What...

JERUSALEM—The massive surge of COVID-19 infections in Israel, one of the most vaccinated countries on earth, is pointing to a complicated path ahead for America.
In June, there were several days with zero new COVID infections in Israel. The country launched its national vaccination campaign in December last year and has one of the highest vaccination rates in the world, with 80 percent of citizens above the age of 12 fully inoculated. COVID, most Israelis thought, had been defeated. All restrictions were lifted and Israelis went back to crowded partying and praying in mask-free venues.
Post-Vaccine Israel Reopens With a Party
Fast forward two months later: Israel reported 9,831 new diagnosed cases on Tuesday, a hairbreadth away from the worst daily figure ever recorded in the country—10,000—at the peak of the third wave. More than 350 people have died of the disease in the first three weeks of August. In a Sunday press conference, the directors of seven public hospitals announced that they could no longer admit any coronavirus patients. With 670 COVID-19 patients requiring critical care, their wards are overflowing and staff are at breaking point.
“I don’t want to frighten you,” coronavirus czar Dr. Salman Zarka told the Israeli parliament this week. “But this is the data. Unfortunately, the numbers don’t lie.”

Jack Guez/AFP via Getty Images

What happened?
The complex and sobering truth is that no single policy or event brought Israel to this crisis, Hagai Levine, a Hebrew University of Jerusalem professor of epidemiology, told The Daily Beast. A deadly set of circumstances came together to put Israel on the precipice, most of which can be summed up as: “We are still in the midst of a pandemic, and there is no silver bullet.”
“All the vectors have influenced the rise in morbidity,” he said.
But the principal causes of Israel’s current predicament are the dominance of the extremely infectious Delta variant, which was carried into the country by Israelis returning from foreign vacations during the weeks in which Israel dropped all restrictive measures—along with the worrisome decrease in vaccine efficacy after about six months.
Israel vaccinated its population almost exclusively with the Pfizer/BioNTech vaccine, which received full FDA approval on Monday and remains the gold standard for the prevention of severe illness due to the coronavirus.
But in early July, with citizens over the age of 60 almost completely vaccinated, Israeli scientists began observing a worrisome rise in infections—if not in severe illness and death—among the double-vaccinated.
Fully vaccinated people with weakened immune systems appeared particularly vulnerable to the aggressive Delta variant.
By mid-July, Sheba Hospital Professor Galia Rahav began to experiment with booster shots for oncology patients, transplant patients, and the hospital’s own staff. A group of 70 elderly vaccinated Israelis with transplanted kidneys were the first to receive a third dose.
The success of Rahav’s trials in boosting immunity at about the sixth-month mark contributed to the Centers for Disease Control decision, announced last week, to begin offering booster shots to Americans in September.
In order to keep severe illness and the number of COVID deaths down, and avoiding a fourth national lockdown, Israel has embarked on an aggressive effort to provide all adults with boosters in a matter of weeks.
As of this week, all Israelis over 30 will be eligible to receive booster shots. By the end of the month, they are expected to be universally available to anyone over the age of 12 who received their second vaccine five months or more ago.
The World’s First Booster Jab Rollout Is Here. This Is What Happened.
Israel will then reconfigure its Green Passports, granting them only to the triple-vaccinated, and limiting their validity to six months. In anticipation of this change, the number of unvaccinated Israelis getting their first shots has tripled since the beginning of August.
The World Health Organization has asked wealthy countries to halt all third vaccines for a period of two months, hoping that a moratorium will allow poorer countries, where few citizens have received even a first inoculation, to catch up. The United States rejected the call and Israel has ignored it.
Asked what has brought Israel to peak transmission even as the country has already provided third doses of vaccines to 1.5 million citizens, Rahav, who has become one of the best known faces of Israel’s public health messaging, sighed, saying, “I think we’re dealing with a very nasty virus. This is the main problem—and we’re learning it the hard way.”
“It is a combination of waning immunity, so that inoculated people get reinfected, and at the same time the very transmissible Delta variant,” Rahav said, adding that Israelis lacked the discipline to revert to mask usage as the numbers began rising. “But it is not an Israeli problem,” she added. “It is everywhere.”
Her conclusion should give pause to American authorities, who face school reopenings as, at best, only 50 percent of eligible adults have been fully vaccinated.
Unlike New Zealand, which aims for zero community transmission of the coronavirus, and imposes lockdowns when even a single positive case is identified, Israeli authorities have opted for a model they are calling “living with corona.”
“Israel really is a pioneer,” Levine, the former chairman of the nation’s Association of Public Health Physicians, said, referring to the groundbreaking vaccination campaign and the country’s efforts, currently underway, to fully reopen schools on Sept. 1 while keeping in place measures aimed at preventing school-driven outbreaks, such as the one that closed the nation down last summer.
“We’ve achieved a plan that is not hermetic,” Zarka, the coronavirus czar, told a local radio station. “Clearly there will be cases of illness at schools… [but] shutting oneself up at home and closing the school system isn’t exactly the solution.”
He has asked the government to impose stricter limitations on the size of cultural and sports events until the incidence of the coronavirus declines.
“Each country has to assess its own epidemiology,” Levine said, “its culture, its public health, the public’s confidence in its health authorities.” Referring to New Zealand, he added that “we can all learn from other countries, but you can’t copy paste other countries’ methods.”
Israel was forced to make quick decisions and in a time of great uncertainty. Levine was among the public health officials who expressed doubts about the wisdom of Israel’s untested move towards nationwide booster vaccination, but he told The Daily Beast that the latest statistics, showing that only 0.2 of the first 1.1 million recipients of the third jab were infected with the coronavirus, proved it had been a “brave decision.”
The last week has shown a significant reduction in morbidity among triple-vaccinated Israelis over the age of 70—the first group to receive the booster.
Like the other experts, Rahav supports schools reopening, but noted that thanks to upcoming Jewish holidays, which will close schools in about 80 percent of the country, Israel will once again be uniquely positioned to serve as a huge laboratory.

The Food and Drug Administration granted full approval to Pfizer-BioNTech's two-dose vaccine Monday for people ages 16 and up, making it the first Covid-19 vaccine to pass this final regulatory hurdle.
"The FDA's approval of this vaccine is a milestone as we continue to battle the Covid-19 pandemic," acting FDA Commissioner Dr. Janet Woodcock said in a statement. "While millions of people have already safely received Covid-19 vaccines, we recognize that for some, the FDA approval of a vaccine may now instill additional confidence to get vaccinated. Today's milestone puts us one step closer to altering the course of this pandemic in the U.S."

Full coverage of the Covid-19 pandemic
Full approval may help persuade some vaccine-hesitant people to get vaccinated. A Kaiser Family Foundation survey from June found that 3 in 10 unvaccinated adults would be more likely to get the shots if a vaccine were fully approved.
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Health
What full FDA approval could change about Covid vaccination
The FDA's decision may also pave the way for more vaccination mandates: Many businesses were waiting for full approval before they required employees to be vaccinated.
Public health experts praised the decision.
"We are ecstatic with anything that could potentially get even one single extra person vaccinated," said Dr. Joseph Khabbaza, a pulmonary and critical care specialist at the Cleveland Clinic.
"Full approval could not come at a more important time, as the highly contagious delta variant continues to drive up caseloads and deaths across the U.S.," Dr. Richard Besser said in a statement. Besser is the Robert Wood Johnson Foundation president and CEO and a former acting director of the Centers for Disease Control and Prevention. "I am hopeful that full approval will address any remaining concerns and will move many people to a 'yes' on vaccination."
Still, Besser said the lack of vaccines in middle- and low-income countries "represents a global failure," adding that "ensuring an adequate supply of vaccines in every country and community must be a health, economic, and moral imperative for the world."
Pfizer CEO Albert Bourla, in a wide-ranging interview Monday with NBC News' Lester Holt, said the FDA's full approval should help ease hesitancy and convince more people to get the shots.
"For those people that they were a little bit reluctant because they wanted to see full approval, now they have the full confirmation of one of the most respected agencies in the world, the FDA, that the ... vaccine is effective and safe," he said.
Bourla also championed a need for booster. “The booster will be needed because of the combination of the delta variant ... and the fact that the immunity after six months starts waning. So a booster dose is a must."
Last week, federal health officials announced that, starting Sept. 20, people who received the Pfizer vaccine will be eligible for third doses eight months after their second doses. The FDA has not yet signed off on a third dose for the general population. However, people with compromised immune systems are able to get the extra shot.
Pfizer's vaccine is one of three in use in the U.S. Moderna has also applied for full approval, also known as a Biologics Licensing Application. Johnson & Johnson has not yet applied for full approval and remains in use under emergency authorization.
Pfizer's product was the first Covid vaccine to gain emergency use authorization, in December. As of Monday, more than 204 million doses of the Pfizer vaccine have been given in the U.S., according to the CDC.
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While Monday's approval does not cover young people ages 12 through 15, that group can still get the Pfizer vaccine through emergency use authorization.
No Covid vaccines have been authorized or approved for use in children under 12. Those are expected later this fall or winter.
Off label use
[url=https://www.nbcnews.com/health/health-news/fda-grants-full-approval-pfizer-s-covid-vaccine-n1277390#anchor-Offlabeluse]Full approval by the FDA of any medication means that doctors are able to prescribe the product "off label" — a practice in which doctors prescribe approved drugs for unapproved uses.
Off label use is common: according to the Agency for Healthcare Research and Quality, 20 percent of prescriptions are written are off label. For example, the diabetes drug metformin is sometimes prescribed for weight loss because one of its side effects is to lower a person's appetite.

Full approval of Pfizer's vaccine means that technically, doctors can give the shots to kids 11 and younger, however, the FDA and pediatricians strongly discourage the practice, citing a lack of safety and efficacy data.
"We are not recommending that children younger than age 12 be vaccinated with this vaccine. It would not be appropriate," Woodcock said during a press briefing Monday.
Vaccine doses for young children will likely be lower than what is currently given to teens and adults.
Kids "are not just small adults," Woodcock said. "We really would have to have the data and the appropriate dose before recommending that children be vaccinated."
Dr. Natasha Burgert, a pediatrician in Overland Park, Kansas, and a national spokesperson for the American Academy of Pediatrics, said that overall, clinicians are unlikely to use the vaccines off label in children.
"We don't give vaccines off label. That'd be very irresponsible," Burgert said.
The AAP urged parents of younger children to wait until the clinical trials in kids are finished. "The clinical trials for the Covid-19 vaccine in children ages 11 years old and younger are underway, and we need to see the data from those studies before we give this vaccine to younger children," the group said in a statement.

Healthcare & Pharmaceuticals $650 Billion World Drug Market.
Pfizer, Moderna seen reaping billions from COVID-19 vaccine booster market
COVID-19 vaccine market booms; Pfizer, Moderna to gain billions
Pfizer, Moderna seen reaping billions from COVID-19 vaccine booster market

Jobs + Free Funding + Your Own Dream Business.

NEW YORK, Aug 13 (Reuters) - Drugmakers Pfizer Inc, BioNTech and Moderna Inc are expected to reap billions of dollars from COVID-19 booster shots in a market that could rival the $6 billion in annual sales for flu vaccines for years to come, analysts and healthcare investors say.



For several months, the companies have said they expect that fully inoculated people will need an extra dose of their vaccines to maintain protection over time and to fend off new coronavirus variants.

Now a growing list of governments, including Chile, Germany and Israel, have decided to offer booster doses to older citizens or people with weak immune systems in the face of the fast-spreading Delta variant.

Investors Daily. Get partners and investors for your small business. Share your dream business idea and receive up to $350,000 in free funding.
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Canada is undoubtedly one of the most sought-after countries for immigration in the world and it isn’t any wonder that Canada welcomes almost 300,000 new immigrants into its borders on an annual basis. So why should you immigrate to Canada?

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Canada’s crime rate is among the lowest in the entire world, which is also a major contributor to the population’s high quality of life. Canadians are extremely conscious of crime and have a zero tolerance policy to many social issues such as domestic abuse and violence. In addition, Canada has had no weapons of mass destruction since 1984 and has signed treaties repudiating their possession.



Send an email to traveljobsworld@gmail.com

With the largest coastline in the world and more lakes than the rest of the world combined, Canada’s natural beauty is unparalleled. Moreover, the country also exhibits impressive urban metropolis areas and breath-taking skyscrapers for the average city goer.

Canada’s infrastructure and economy work in perfect unison to produce a well-run country. Canada is also ranked 11th among the wealthiest countries in the world and is also a member of the Organization for Economic Co-operation and Development (OECD). As with a developed nation, the Canadian economy is dominated by the service industry, which employs about three quarters of Canadians



According to recent statistics, the average Canadian lives up to the age of 81. We speculate that the fresh air and vast open spaces contribute to Canada’s high quality of life. The aged community in Canada are therefore well-looked after.

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